Vaccination and isolation based control design of the COVID-19 pandemic based on adaptive neuro fuzzy inference system optimized with the genetic algorithm.

The study of the COVID-19 pandemic is of pivotal importance due to its tremendous global impacts. This paper aims to control this disease using an optimal strategy comprising two methods: isolation and vaccination. In this regard, an optimized Adaptive Neuro-Fuzzy Inference System (ANFIS) is developed using the Genetic Algorithm (GA) to control the dynamic model of the COVID-19 termed SIDARTHE (Susceptible, Infected, Diagnosed, Ailing, Recognized, Threatened, Healed, and Extinct). The number of diagnosed and recognized people is reduced by isolation, and the number of susceptible people is reduced by vaccination. The GA generates optimal control efforts related to the random initial number of each chosen group as the input data for ANFIS to train Takagi-Sugeno (T-S) fuzzy structure coefficients. Also, three theorems are presented to indicate the positivity, boundedness, and existence of the solutions in the presence of the controller. The performance of the proposed system is evaluated through the mean squared error (MSE) and the root-mean-square error (RMSE). The simulation results show a significant decrease in the number of diagnosed, recognized, and susceptible individuals by employing the proposed controller, even with a 70% increase in transmissibility caused by various variants.

Vaccination and isolation based control design of the COVID-19 pandemic based on adaptive neuro fuzzy inference system optimized with the genetic algorithm

The study of the COVID-19 pandemic is of pivotal importance due to its tremendous global impacts. This paper aims to control this disease using an optimal strategy comprising two methods: isolation and vaccination. In this regard, an optimized Adaptive Neuro-Fuzzy Inference System (ANFIS) is developed using the Genetic Algorithm (GA) to control the dynamic model of the COVID-19 termed SIDARTHE (Susceptible, Infected, Diagnosed, Ailing, Recognized, Threatened, Healed, and Extinct). The number of diagnosed and recognized people is reduced by isolation, and the number of susceptible people is reduced by vaccination. The GA generates optimal control efforts related to the random initial number of each chosen group as the input data for ANFIS to train Takagi–Sugeno (T–S) fuzzy structure coefficients. Also, three theorems are presented to indicate the positivity, boundedness, and existence of the solutions in the presence of the controller. The performance of the proposed system is evaluated through the mean squared error (MSE) and the root-mean-square error (RMSE). The simulation results show a significant decrease in the number of diagnosed, recognized, and susceptible individuals by employing the proposed controller, even with a 70% increase in transmissibility caused by various variants.

Parameter Estimation and Prediction of COVID-19 Epidemic Turning Point and Ending Time of a Case Study on SIR/SQAIR Epidemic Models.

In this paper, the SIR epidemiological model for the COVID-19 with unknown parameters is considered in the first strategy. Three curves (S, I, and R) are fitted to the real data of South Korea, based on a detailed analysis of the actual data of South Korea, taken from the Korea Disease Control and Prevention Agency (KDCA). Using the least square method and minimizing the error between the fitted curve and the actual data, unknown parameters, like the transmission rate, recovery rate, and mortality rate, are estimated. The goodness of fit model is investigated with two criteria (SSE and RMSE), and the uncertainty range of the estimated parameters is also presented. Also, using the obtained determined model, the possible ending time and the turning point of the COVID-19 outbreak in the United States are predicted. Due to the lack of treatment and vaccine, in the next strategy, a new group called quarantined people is added to the proposed model. Also, a hidden state, including asymptomatic individuals, which is very common in COVID-19, is considered to make the model more realistic and closer to the real world. Then, the SIR model is developed into the SQAIR model. The delay in the recovery of the infected person is also considered as an unknown parameter. Like the previous steps, the possible ending time and the turning point in the United States are predicted. The model obtained in each strategy for South Korea is compared with the actual data from KDCA to prove the accuracy of the estimation of the parameters.

Optimal Control Design of Impulsive SQEIAR Epidemic Models with Application to COVID-19.

This paper presents a SEIAR-type model considering quarantined individuals (Q), called SQEIAR model. The dynamic of SQEIAR model is defined by six ordinary differential equations that describe the numbers of Susceptible, Quarantined, Exposed, Infected, Asymptomatic, and Recovered individuals. The goal of this paper is to reduce the size of susceptible, infected, exposed and asymptomatic groups to consequently eradicate the infection by using two actions: the quarantine and the treatment of infected people. To reach this purpose, optimal control theory is presented to control the epidemic model over free terminal optimal time control with an optimal cost. Pontryagin's maximum principle is used to characterize the optimal controls and the optimal final time. Also, an impulsive epidemic model of SQEIAR is considered to deal with the potential suddenly increased in population caused by immigration or travel. Since this model is suitable to describe the COVID-19 pandemic, especial attention is devoted to this case. Thus, numerical simulations are given to prove the accuracy of the theoretical claims and applied to the particular data of this infection. Moreover, numerical computations of the COVID-19 are compared with diseases like Ebola and Influenza. In addition, the controller is evaluated with system parameters identified by using actual data of China. Finally, the controller tuned with the estimated parameters of the Chinese data is applied to the actual data of Spain to compare the quarantine and treatment policies in both countries.